FNTA

Across TCGA pan-cancer cohorts, FNTA mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated FNTA data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FNTA mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated FNTA expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where FNTA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.963	0.759	.004	55	view →
CCRCC	DFS	Median	II,III,IV	0.999	0.759	.005	14	view →
LSCC	DFS	Median	II,III,IV	1.000	0.834	.004	11	view →
LUAD	OS	Tertile	All	0.597	1.000	.005	10	view →
OV	DFS	Median	All	0.976	0.592	.024	4	view →
UCEC	OS	Median	II,III,IV	0.674	0.936	.042	4	view →
PDAC	DFS	Tertile	IV	0.199	0.752	.024	3	view →
GBM	DFS	Quartile	All	0.617	0.817	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

FNTA–HNSC (OS)

Open the HNSC breakdown →