FNIP2

Across TCGA patient cohorts, FNIP2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FNIP2-associated genes across cancer lineages are Caspase-7-cleavedD198, ERK2, and MEK1. Each is linked with FNIP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FNIP2-to-partner and partner-to-FNIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FNIP2-low versus FNIP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FNIP2→partner) and Y-score (partner→FNIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.694	+1.604	<.001	.010	3	3
UCEC	ERK2 →	+0.231	+3.087	<.001	<.001	3	2
UCEC	MEK1 →	+0.461	+2.222	<.001	<.001	3	2
UCEC	MSH2 →	-0.319	-2.558	<.001	<.001	3	2
UCEC	PDCD4 →	-0.537	-2.087	<.001	.004	3	2
UCEC	Rad50 →	-0.229	-1.700	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Caspase-7-cleavedD198 by FNIP2 expression — UCEC

Explore this box plot interactively →