FNDC7

Across TCGA cell cohorts, FNDC7 mutation is significantly associated with the RNA expression of many other genes, with 411 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FNDC7-associated genes across cancer lineages are OR4B1, OR12D3, and TAAR8. Each is linked with FNDC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both FNDC7-to-partner and partner-to-FNDC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4B1 grouped by FNDC7-low versus FNDC7-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FNDC7→partner) and Y-score (partner→FNDC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR4B1 →	+0.055	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR12D3 →	+0.035	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR56A5 →	+0.111	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	IQCF3 →	+0.045	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR12D1 →	+0.042	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 411 associations by consensus.

OR4B1 by FNDC7 expression — LUNG_SCLC

Explore this box plot interactively →