FNDC4

Across TCGA patient cohorts, FNDC4 mutation is significantly associated with the immune_cell of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FNDC4-associated genes across cancer lineages are Th2 cells, CD8+ Tcm, and CD8+ Tem. Each is linked with FNDC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FNDC4-to-partner and partner-to-FNDC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Th2 cells grouped by FNDC4-low versus FNDC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FNDC4→partner) and Y-score (partner→FNDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Th2 cells →	+0.182	+2.321	.045	.036	3	2
UCEC	CD8+ Tcm →	+0.031	+2.350	.001	.031	3	1
UCEC	CD8+ Tem →	+0.003	+4.606	<.001	.044	3	1
UCEC	Adipocytes →	+0.019	+2.144	.035	.036	3	1
UCEC	DC →	+0.029	+2.859	.004	.004	3	1
UCEC	Endothelial cells →	-0.039	-2.279	.042	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Th2 cells by FNDC4 expression — UCEC

Explore this box plot interactively →