FNDC1

Across TCGA patient cohorts, FNDC1 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FNDC1-associated genes across cancer lineages are Bad_pS112, Caveolin-1, and 4E-BP1. Each is linked with FNDC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FNDC1-to-partner and partner-to-FNDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bad_pS112 grouped by FNDC1-low versus FNDC1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FNDC1→partner) and Y-score (partner→FNDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Bad_pS112 →	-0.174	-3.000	.048	.033	3	3
STAD	Caveolin-1 →	-0.691	-2.584	.029	.010	3	3
LUAD	4E-BP1 →	+0.283	+2.459	.039	.020	2	4
BLCA	PCNA →	+0.261	+3.169	.009	.019	3	3
COAD	eIF4E →	+0.124	+1.498	.013	.032	3	3
UCEC	MEK1 →	+0.276	+1.632	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Bad_pS112 by FNDC1 expression — STAD

Explore this box plot interactively →