FNDC1

Across TCGA cell cohorts, FNDC1 mutation is significantly associated with the RNA expression of many other genes, with 811 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FNDC1-associated genes across cancer lineages are NIF3L1, SSX2, and ERI1. Each is linked with FNDC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FNDC1-to-partner and partner-to-FNDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NIF3L1 grouped by FNDC1-low versus FNDC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FNDC1→partner) and Y-score (partner→FNDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NIF3L1 →	+0.334	+2.764	.001	<.001	3	3
BREAST	SSX2 →	+0.663	+3.758	.001	.007	3	3
LARGE_INTESTINE	ERI1 →	+0.535	+1.721	.002	.003	3	2
LARGE_INTESTINE	HOXA2 →	-0.654	-2.044	.002	.001	3	2
LARGE_INTESTINE	SLC25A11 →	+0.554	+3.409	<.001	<.001	3	2
LARGE_INTESTINE	NDUFC1 →	+0.513	+2.130	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 811 associations by consensus.

NIF3L1 by FNDC1 expression — LARGE_INTESTINE

Explore this box plot interactively →