FN3KRP

Across TCGA pan-cancer cohorts, FN3KRP RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FN3KRP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FN3KRP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FN3KRP is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

HNSC, KIRP, and LIHC are the cancer types where FN3KRP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FN3KRP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.960	<.001	12	view →
KIRP	All	IV	+0.797	<.001	10	view →
LIHC	Male	All	+0.910	<.001	9	view →
LUAD	All	II,III,IV	+0.370	<.001	9	view →
KICH	Female	All	−1.614	<.001	8	view →
LUSC	Female	All	+0.729	<.001	6	view →
STAD	All	II,III,IV	+0.586	.003	4	view →
COAD	All	All	+0.297	.002	4	view →
KIRC	All	All	+0.238	.001	4	view →
BRCA	All	II,III,IV	+0.198	.019	4	view →
CHOL	Male	All	+1.670	<.001	3	view →
BLCA	Female	All	+0.637	.016	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FN3KRP–HNSC

Open the HNSC breakdown →