FN3K

Across TCGA pan-cancer cohorts, FN3K RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated FN3K data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher FN3K RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FN3K expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCEC show a favorable association.

UCS, BRCA, and UCEC are the cancer types where FN3K RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Quartile	III,IV	0.238	0.771	<.001	78	view →
BRCA	OS	Quartile	III,IV	0.948	0.724	<.001	68	view →
UCEC	OS	Tertile	All	0.775	0.533	<.001	66	view →
ACC	DFS	Quartile	II,III,IV	0.849	0.397	.004	44	view →
ESCA	OS	Tertile	All	0.574	0.777	.005	44	view →
PAAD	DFS	Tertile	All	0.469	0.247	<.001	42	view →
KIRC	DFS	Tertile	All	0.695	0.521	<.001	33	view →
COAD	OS	Median	IV	0.826	0.445	.001	17	view →
HNSC	DFS	Median	IV	0.709	0.572	.005	16	view →
PRAD	DFS	Median	All	0.853	0.914	.021	16	view →
LGG	OS	Quartile	All	0.541	0.440	.006	14	view →
SARC	OS	Tertile	All	0.712	0.431	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

FN3K–UCS (OS)

Open the UCS breakdown →