FN3K

Across TCGA pan-cancer cohorts, FN3K Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FN3K data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher FN3K Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FN3K expression acts as an unfavorable survival marker.

SCLC, ESCA, and PRAD are the cancer types where FN3K Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.082	0.708	<.001	36	view →
ESCA	OS	Median	II,III,IV	0.164	0.702	.001	33	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FN3K–SCLC (OS)

Open the SCLC breakdown →