FN3K

Across TCGA pan-cancer cohorts, FN3K mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FN3K data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FN3K mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FN3K expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and GBM are the cancer types where FN3K mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.837	0.385	<.001	33	view →
CCRCC	DFS	Median	All	0.915	0.538	.003	11	view →
GBM	OS	Quartile	All	0.284	0.693	.015	6	view →
HNSC	DFS	Quartile	II,III,IV	0.877	0.988	.036	2	view →
LSCC	DFS	Median	All	1.000	0.905	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FN3K–PDAC (DFS)

Open the PDAC breakdown →