FN1

Across TCGA pan-cancer cohorts, FN1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated FN1 data layer compared with 27 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FN1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FN1 expression acts as an unfavorable survival marker.

PDAC, COAD, and LSCC are the cancer types where FN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.296	0.521	.005	39	view →
COAD	DFS	Median	II,III,IV	0.878	1.000	.017	36	view →
LSCC	DFS	Tertile	II,III,IV	0.494	0.896	.005	30	view →
CCRCC	DFS	Median	III,IV	0.399	0.932	.022	18	view →
LUAD	OS	Tertile	All	0.395	0.831	.006	13	view →
GBM	OS	Median	All	0.275	0.479	.023	5	view →
HNSC	DFS	Median	IV	0.566	0.763	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

FN1–PDAC (DFS)

Open the PDAC breakdown →