FN1

Across TCGA patient cohorts, FN1 mutation is significantly associated with the RNA expression of many other genes, with 8,982 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FN1-associated genes across cancer lineages are POLE2, SNRNP25, and UQCRH. Each is linked with FN1 in more than 5 cancer types. Because this analysis shows association rather than direction, both FN1-to-partner and partner-to-FN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLE2 grouped by FN1-low versus FN1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FN1→partner) and Y-score (partner→FN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	POLE2 →	+0.441	+3.472	.005	.002	3	6
UCEC	SNRNP25 →	+0.462	+1.660	<.001	<.001	3	6
UCEC	UQCRH →	+0.526	+1.075	.001	<.001	3	6
UCEC	TIPIN →	+0.447	+1.511	<.001	<.001	3	6
LUSC	OIP5 →	+0.620	+2.026	<.001	.005	3	6
UCEC	PSMC3IP →	+0.556	+1.233	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,982 associations by consensus.

POLE2 by FN1 expression — STAD

Explore this box plot interactively →