FMR1

Across TCGA pan-cancer cohorts, FMR1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated FMR1 data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FMR1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FMR1 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

PDAC, COAD, and OV are the cancer types where FMR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.603	0.850	.002	56	view →
COAD	DFS	Tertile	All	1.000	0.896	.023	30	view →
OV	DFS	Median	All	0.858	1.000	.027	12	view →
LUAD	OS	Tertile	III,IV	1.000	0.689	.013	11	view →
HNSC	DFS	Quartile	All	0.331	0.947	.024	6	view →
LSCC	DFS	Quartile	II,III,IV	0.800	0.451	.027	4	view →
CCRCC	DFS	Median	II,III,IV	0.827	0.359	.023	2	view →
GBM	OS	Tertile	All	0.484	0.295	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

FMR1–PDAC (DFS)

Open the PDAC breakdown →