FMR1

Across TCGA patient cohorts, FMR1 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,658 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FMR1-associated proteins across cancer lineages are STAG2, CUL4B, and HMGB3. Each is linked with FMR1 in more than 6 cancer types. Because this analysis shows association rather than direction, both FMR1-to-partner and partner-to-FMR1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FMR1 versus STAG2 in COAD, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FMR1→partner) and Y-score (partner→FMR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	STAG2 →	+0.317	+0.567	<.001	<.001	3	7
OV	CUL4B →	+0.323	+0.669	.002	.009	3	6
LSCC	HMGB3 →	+0.703	+0.635	<.001	<.001	3	6
GBM	SAE1 →	+0.323	+0.375	<.001	.001	3	5
HNSC	FAM50A →	+0.299	+0.587	<.001	<.001	3	5
COAD	HUWE1 →	+0.168	+0.307	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,658 associations by consensus.

FMR1 vs STAG2 — COAD

Explore this scatter interactively →