FMR1

Across TCGA patient cohorts, FMR1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,357 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FMR1-associated genes across cancer lineages are VMA21, DKC1, and AIFM1. Each is linked with FMR1 in more than 6 cancer types. Because this analysis shows association rather than direction, both FMR1-to-partner and partner-to-FMR1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FMR1 versus VMA21 in LUAD, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMR1→partner) and Y-score (partner→FMR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	VMA21 →	+0.564	+0.218	<.001	<.001	3	7
HNSC	DKC1 →	+0.607	+0.240	.001	.001	2	7
OV	AIFM1 →	+0.790	+0.524	.001	.001	2	7
COAD	BCAP31 →	+0.523	+0.362	<.001	<.001	3	6
BRCA	EOLA2 →	+0.763	+0.282	<.001	.002	3	6
HNSC	NKRF →	+0.532	+0.182	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,357 associations by consensus.

FMR1 vs VMA21 — LUAD

Explore this scatter interactively →