FMR1

Across TCGA patient cohorts, FMR1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMR1-associated genes across cancer lineages are Rad50, ATM, and FOXO3a_pS318_S321. Each is linked with FMR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FMR1-to-partner and partner-to-FMR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by FMR1-low versus FMR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMR1→partner) and Y-score (partner→FMR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.133	-1.649	.039	.009	3	3
UCEC	ATM →	-0.291	-1.571	.015	.015	3	3
LUSC	FOXO3a_pS318_S321 →	-0.135	-3.142	.031	.019	3	2
UCEC	ERK2 →	+0.170	+1.387	<.001	.001	3	2
UCEC	FoxM1 →	+0.149	+1.387	.029	.001	3	2
UCEC	mTOR_pS2448 →	-0.080	-1.234	.042	.038	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Rad50 by FMR1 expression — UCEC

Explore this box plot interactively →