FMR1

Across TCGA cell cohorts, FMR1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. CNS shows the largest number of these associations.

The most reproducible FMR1-associated genes across cancer lineages are IQCF5, PRAMEF10, and PRAMEF33. Each is linked with FMR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FMR1-to-partner and partner-to-FMR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by FMR1-low versus FMR1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMR1→partner) and Y-score (partner→FMR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	2
CNS	PRAMEF10 →	+0.386	+5.754	<.001	.002	3	1
CNS	PRAMEF33 →	+0.576	+5.321	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR9I1 →	+0.020	+5.266	<.001	.001	3	1
OVARY	RBMY1A1 →	+0.143	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

IQCF5 by FMR1 expression — BLOOD_Leukemia

Explore this box plot interactively →