FMOD

Across TCGA patient cohorts, FMOD mutation is significantly associated with the RNA expression of many other genes, with 2,116 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMOD-associated genes across cancer lineages are RNA5SP419, RNA5SP417, and RNA5SP422. Each is linked with FMOD in more than 1 cancer types. Because this analysis shows association rather than direction, both FMOD-to-partner and partner-to-FMOD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP419 grouped by FMOD-low versus FMOD-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMOD→partner) and Y-score (partner→FMOD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP419 →	+0.680	+5.102	<.001	.002	3	2
LUSC	RNA5SP417 →	+0.951	+4.882	<.001	<.001	3	2
LUSC	RNA5SP422 →	+0.738	+4.733	<.001	.004	3	2
LUSC	RNA5SP416 →	+0.616	+4.733	<.001	.004	3	2
LUSC	RNA5SP421 →	+0.685	+4.438	<.001	.006	3	2
LUSC	RNA5SP420 →	+0.687	+4.309	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,116 associations by consensus.

RNA5SP419 by FMOD expression — LUSC

Explore this box plot interactively →