FMOD

Across TCGA patient cohorts, FMOD mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMOD-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and eIF4G. Each is linked with FMOD in more than 1 cancer types. Because this analysis shows association rather than direction, both FMOD-to-partner and partner-to-FMOD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FMOD-low versus FMOD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMOD→partner) and Y-score (partner→FMOD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.677	+2.720	.002	.003	3	2
UCEC	14-3-3_beta →	-0.107	-2.432	.005	.018	3	1
UCEC	eIF4G →	+0.256	+1.678	.031	.023	3	1
UCEC	ERK2 →	+0.217	+2.807	.003	.003	3	1
UCEC	JNK2 →	+0.298	+2.486	<.001	.009	3	1
UCEC	Ku80 →	+0.202	+1.335	.026	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Caspase-7-cleavedD198 by FMOD expression — UCEC

Explore this box plot interactively →