FMOD

Across TCGA cell cohorts, FMOD mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FMOD-associated genes across cancer lineages are APOC4, OR14A16, and OR8B3. Each is linked with FMOD in more than 1 cancer types. Because this analysis shows association rather than direction, both FMOD-to-partner and partner-to-FMOD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOC4 grouped by FMOD-low versus FMOD-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMOD→partner) and Y-score (partner→FMOD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	APOC4 →	+0.064	+4.736	<.001	.009	3	1
CNS	OR14A16 →	+0.032	+5.321	<.001	.005	3	1
CNS	OR8B3 →	+0.033	+4.981	<.001	.008	3	1
BLOOD_Leukemia	GML →	+0.074	+3.567	<.001	.003	3	1
BLOOD_Leukemia	BHLHE23 →	+1.102	+3.691	.002	.005	3	1
BLOOD_Leukemia	GSC →	+1.249	+3.948	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

APOC4 by FMOD expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →