FMO6P

Across TCGA patient cohorts, FMO6P mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMO6P-associated genes across cancer lineages are EGFR_pY1068, ERK2, and FASN. Each is linked with FMO6P in more than 1 cancer types. Because this analysis shows association rather than direction, both FMO6P-to-partner and partner-to-FMO6P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FMO6P-low versus FMO6P-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMO6P→partner) and Y-score (partner→FMO6P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.274	-3.584	.023	.002	3	1
UCEC	ERK2 →	+0.197	+3.584	.034	.002	3	1
UCEC	FASN →	+0.508	+3.321	.007	.010	3	1
UCEC	ACC1 →	+0.496	+3.013	.004	.018	3	1
UCEC	Ku80 →	+0.283	+2.472	.013	.011	3	1
UCEC	p70-S6K_pT389 →	-0.215	-3.160	.019	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR_pY1068 by FMO6P expression — UCEC

Explore this box plot interactively →