FMO4

Across TCGA patient cohorts, FMO4 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMO4-associated genes across cancer lineages are XBP1, ACC1, and Caspase-7-cleavedD198. Each is linked with FMO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FMO4-to-partner and partner-to-FMO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XBP1 grouped by FMO4-low versus FMO4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMO4→partner) and Y-score (partner→FMO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	XBP1 →	-0.374	-3.000	.003	.035	3	2
UCEC	ACC1 →	+0.268	+2.115	.033	.017	3	2
UCEC	Caspase-7-cleavedD198 →	+0.592	+2.019	.003	.005	3	2
UCEC	14-3-3_beta →	-0.091	-1.847	.008	.049	3	1
UCEC	EGFR →	-0.143	-3.459	.009	.005	3	1
UCEC	ACC_pS79 →	+0.276	+1.736	.021	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

XBP1 by FMO4 expression — SKCM

Explore this box plot interactively →