FMO4

Across TCGA cell cohorts, FMO4 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FMO4-associated genes across cancer lineages are UTF1, GSTA5, and CNMD. Each is linked with FMO4 in more than 2 cancer types. Because this analysis shows association rather than direction, both FMO4-to-partner and partner-to-FMO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UTF1 grouped by FMO4-low versus FMO4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMO4→partner) and Y-score (partner→FMO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	UTF1 →	+0.010	+4.022	<.001	.006	3	3
CNS	GSTA5 →	+0.030	+4.981	<.001	.008	3	2
SKIN	CNMD →	+0.067	+3.658	.002	.005	3	2
LUNG_SCLC	ART1 →	+0.381	+4.039	<.001	.003	3	1
LUNG_SCLC	IZUMO2 →	+0.380	+3.946	.008	.002	3	1
SOFT_TISSUE	IFNA8 →	+0.038	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

UTF1 by FMO4 expression — SKIN

Explore this box plot interactively →