FMO3

Across TCGA patient cohorts, FMO3 mutation is significantly associated with the RNA expression of many other genes, with 2,478 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMO3-associated genes across cancer lineages are UBAC1, MLX, and GMNN. Each is linked with FMO3 in more than 3 cancer types. Because this analysis shows association rather than direction, both FMO3-to-partner and partner-to-FMO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBAC1 grouped by FMO3-low versus FMO3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMO3→partner) and Y-score (partner→FMO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	UBAC1 →	+0.252	+1.341	.006	.008	3	4
UCEC	MLX →	+0.559	+2.662	<.001	<.001	3	3
UCEC	GMNN →	+0.602	+3.459	.003	.005	3	3
UCEC	CERT1 →	+0.577	+1.797	.005	.008	3	3
UCEC	BSPRY →	+0.635	+3.708	.005	<.001	3	3
UCEC	TCF19 →	+0.712	+2.815	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,478 associations by consensus.

UBAC1 by FMO3 expression — SKCM

Explore this box plot interactively →