FMO3

Across TCGA patient cohorts, FMO3 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMO3-associated genes across cancer lineages are CD20, JNK2, and FoxM1. Each is linked with FMO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FMO3-to-partner and partner-to-FMO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD20 grouped by FMO3-low versus FMO3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMO3→partner) and Y-score (partner→FMO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	CD20 →	-0.098	-2.974	.034	.035	3	2
UCEC	JNK2 →	+0.277	+3.196	<.001	.009	3	2
UCEC	FoxM1 →	+0.222	+2.222	.043	.011	3	2
UCEC	MEK1 →	+0.491	+2.906	.001	.001	3	2
UCEC	PCNA →	+0.245	+2.000	.007	.030	3	2
UCEC	ATM →	-0.618	-2.308	.001	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

CD20 by FMO3 expression — BLCA

Explore this box plot interactively →