FMO3

Across TCGA cell cohorts, FMO3 mutation is significantly associated with the mutation status of many other genes, with 1,099 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FMO3-associated genes across cancer lineages are TTC7B, UNKL, and TNPO2. Each is linked with FMO3 in more than 2 cancer types. Because this analysis shows association rather than direction, both FMO3-to-partner and partner-to-FMO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTC7B grouped by FMO3-low versus FMO3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMO3→partner) and Y-score (partner→FMO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TTC7B →	+4.247	+4.554	.001	.001	1	3
BLOOD_Lymphoma	UNKL →	+5.832	+5.169	<.001	<.001	1	3
SKIN	TNPO2 →	+3.532	+3.357	.005	.005	1	3
CNS	ABCC5 →	+5.044	+5.614	.003	.003	1	3
SKIN	TGM7 →	+4.117	+3.638	.002	.002	1	3
SKIN	COL4A5 →	+2.362	+2.943	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,099 associations by consensus.

TTC7B by FMO3 expression — BLOOD_Lymphoma

Explore this box plot interactively →