FMO2

Across TCGA patient cohorts, FMO2 mutation is significantly associated with the RNA expression of many other genes, with 3,179 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMO2-associated genes across cancer lineages are ALMS1-IT1, LINC00941, and ZNF519P4. Each is linked with FMO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FMO2-to-partner and partner-to-FMO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALMS1-IT1 grouped by FMO2-low versus FMO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMO2→partner) and Y-score (partner→FMO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ALMS1-IT1 →	+0.352	+3.480	.002	.002	3	3
UCEC	LINC00941 →	+0.404	+2.959	<.001	.001	3	3
UCEC	ZNF519P4 →	+0.203	+2.373	<.001	.004	3	3
UCEC	MAP2K1 →	+0.584	+2.447	<.001	.001	3	3
SKCM	KCTD13 →	+0.352	+2.231	.002	.005	3	3
SKCM	GFPT1 →	+0.457	+3.334	.008	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,179 associations by consensus.

ALMS1-IT1 by FMO2 expression — UCEC

Explore this box plot interactively →