FMO2

Across TCGA patient cohorts, FMO2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMO2-associated genes across cancer lineages are ETS-1, JNK2, and Notch1. Each is linked with FMO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FMO2-to-partner and partner-to-FMO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ETS-1 grouped by FMO2-low versus FMO2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMO2→partner) and Y-score (partner→FMO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ETS-1 →	-0.234	-1.584	.031	.035	3	2
UCEC	JNK2 →	+0.262	+2.087	<.001	.005	3	2
UCEC	Notch1 →	+0.129	+1.678	.017	.023	3	2
UCEC	ATM →	-0.444	-1.678	.010	.023	3	2
UCEC	Di-Ras3 →	-0.130	-3.308	.022	.009	3	2
SKCM	N-Cadherin →	+0.158	+1.874	.038	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ETS-1 by FMO2 expression — SKCM

Explore this box plot interactively →