FMO2

Across TCGA cell cohorts, FMO2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FMO2-associated genes across cancer lineages are OR11H6, MS4A10, and MSGN1. Each is linked with FMO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FMO2-to-partner and partner-to-FMO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H6 grouped by FMO2-low versus FMO2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMO2→partner) and Y-score (partner→FMO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR11H6 →	+0.035	+5.321	<.001	.005	3	1
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1
LARGE_INTESTINE	MSGN1 →	+0.069	+3.345	<.001	.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.210	+3.425	.003	<.001	3	1
LARGE_INTESTINE	MINAR2 →	+0.027	+2.882	.003	.005	3	1
LARGE_INTESTINE	C16orf96 →	+0.456	+3.743	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

OR11H6 by FMO2 expression — CNS

Explore this box plot interactively →