FMO1

Across TCGA patient cohorts, FMO1 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMO1-associated genes across cancer lineages are eIF4E, EGFR_pY1068, and Annexin-1. Each is linked with FMO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FMO1-to-partner and partner-to-FMO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by FMO1-low versus FMO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMO1→partner) and Y-score (partner→FMO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.259	+2.906	.001	.001	3	3
UCEC	EGFR_pY1068 →	-0.286	-2.000	.003	.010	3	2
UCEC	Annexin-1 →	+0.752	+2.720	<.001	.003	3	2
UCEC	c-Met →	-0.245	-3.169	.036	<.001	3	2
SKCM	XBP1 →	-0.195	-2.321	.037	.032	3	2
LUAD	ETS-1 →	+0.167	+3.321	.015	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

eIF4E by FMO1 expression — UCEC

Explore this box plot interactively →