FMNL3

Across TCGA pan-cancer cohorts, FMNL3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated FMNL3 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher FMNL3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FMNL3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

LSCC, CCRCC, and OV are the cancer types where FMNL3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.579	0.829	.001	29	view →
CCRCC	DFS	Quartile	III,IV	0.897	0.293	<.001	28	view →
OV	DFS	Tertile	All	0.441	0.884	.015	16	view →
PDAC	OS	Quartile	II,III,IV	1.000	0.728	.017	5	view →
HNSC	DFS	Tertile	IV	0.474	0.820	.004	4	view →
UCEC	OS	Tertile	II,III,IV	0.662	1.000	.042	4	view →
LUAD	OS	Tertile	III,IV	0.569	0.842	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

FMNL3–LSCC (DFS)

Open the LSCC breakdown →