FMNL3

Across TCGA patient cohorts, FMNL3 mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMNL3-associated genes across cancer lineages are ATM, GAPDH, and ACC1. Each is linked with FMNL3 in more than 3 cancer types. Because this analysis shows association rather than direction, both FMNL3-to-partner and partner-to-FMNL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FMNL3-low versus FMNL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMNL3→partner) and Y-score (partner→FMNL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.433	-2.649	<.001	<.001	3	4
UCEC	GAPDH →	+0.495	+2.584	<.001	<.001	3	3
UCEC	ACC1 →	+0.228	+1.375	.024	.020	3	3
COAD	Lck →	+0.330	+1.900	.009	.030	3	3
UCEC	NF2 →	+0.211	+1.652	<.001	.005	3	3
COAD	Caspase-7-cleavedD198 →	+1.341	+3.601	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

ATM by FMNL3 expression — UCEC

Explore this box plot interactively →