FMNL3

Across TCGA cell cohorts, FMNL3 mutation is significantly associated with the RNA expression of many other genes, with 720 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FMNL3-associated genes across cancer lineages are GPR119, MSGN1, and CARD18. Each is linked with FMNL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FMNL3-to-partner and partner-to-FMNL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR119 grouped by FMNL3-low versus FMNL3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMNL3→partner) and Y-score (partner→FMNL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GPR119 →	+0.025	+3.196	<.001	.007	3	1
SKIN	MSGN1 →	+0.045	+4.022	<.001	.006	3	1
SKIN	CARD18 →	+0.079	+3.347	.006	.005	3	1
LUNG_SCLC	OPRPN →	+0.139	+5.029	<.001	.006	3	1
LUNG_SCLC	OR9I1 →	+0.023	+5.643	<.001	.002	3	1
BLOOD_Leukemia	TMEM114 →	+0.038	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 720 associations by consensus.

GPR119 by FMNL3 expression — SKIN

Explore this box plot interactively →