FMNL2

Across TCGA patient cohorts, FMNL2 mutation is significantly associated with the RNA expression of many other genes, with 4,091 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMNL2-associated genes across cancer lineages are PRPF18, RFWD3, and PGAM1. Each is linked with FMNL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FMNL2-to-partner and partner-to-FMNL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRPF18 grouped by FMNL2-low versus FMNL2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMNL2→partner) and Y-score (partner→FMNL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PRPF18 →	+0.487	+2.076	<.001	.001	3	3
UCEC	RFWD3 →	+0.527	+2.099	<.001	<.001	3	3
UCEC	PGAM1 →	+0.685	+1.691	<.001	<.001	3	3
SKCM	SPATA5L1 →	+0.447	+2.971	.001	<.001	3	3
UCEC	RRM2 →	+0.783	+1.857	<.001	<.001	3	3
UCEC	GCC1 →	+0.428	+1.857	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,091 associations by consensus.

PRPF18 by FMNL2 expression — SKCM

Explore this box plot interactively →