FMNL2

Across TCGA patient cohorts, FMNL2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMNL2-associated genes across cancer lineages are TFRC, MEK1, and Chk1. Each is linked with FMNL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FMNL2-to-partner and partner-to-FMNL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by FMNL2-low versus FMNL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMNL2→partner) and Y-score (partner→FMNL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.599	+2.807	<.001	.002	3	3
UCEC	MEK1 →	+0.438	+2.000	<.001	<.001	3	2
SKCM	Chk1 →	+0.184	+3.597	.016	.001	3	2
UCEC	Rictor_pT1135 →	-0.087	-1.847	.008	.007	3	2
UCEC	Src_pY527 →	-0.369	-2.222	.008	.009	3	2
UCEC	Stathmin →	+0.106	+1.459	.016	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

TFRC by FMNL2 expression — UCEC

Explore this box plot interactively →