FMN2

Across TCGA patient cohorts, FMN2 mutation is significantly associated with the total protein of many other genes, with 98 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FMN2-associated genes across cancer lineages are eIF4E, JNK2, and mTOR. Each is linked with FMN2 in more than 4 cancer types. Because this analysis shows association rather than direction, both FMN2-to-partner and partner-to-FMN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by FMN2-low versus FMN2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FMN2→partner) and Y-score (partner→FMN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.246	+2.762	<.001	<.001	3	5
COAD	JNK2 →	-0.176	-1.700	.004	.038	3	4
COAD	mTOR →	-0.185	-2.000	.007	.029	3	4
COAD	Stathmin →	+0.154	+1.856	.002	.004	3	4
COAD	Chk1 →	+0.300	+1.856	<.001	.004	3	4
LUSC	4E-BP1_pT70 →	+0.132	+1.428	.022	.025	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 98 associations by consensus.

eIF4E by FMN2 expression — COAD

Explore this box plot interactively →