FLYWCH1

Across TCGA pan-cancer cohorts, FLYWCH1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FLYWCH1 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FLYWCH1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FLYWCH1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where FLYWCH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.295	0.755	.001	30	view →
LUAD	DFS	Quartile	II,III,IV	0.699	1.000	.017	7	view →
PDAC	DFS	Median	All	0.249	0.756	.019	5	view →
UCEC	DFS	Median	All	1.000	0.935	.043	2	view →
GBM	DFS	Quartile	All	0.457	0.271	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FLYWCH1–HNSC (DFS)

Open the HNSC breakdown →