FLYWCH1

Across TCGA patient cohorts, FLYWCH1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLYWCH1-associated genes across cancer lineages are Caspase-7-cleavedD198, Fibronectin, and p62 Lck ligand. Each is linked with FLYWCH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FLYWCH1-to-partner and partner-to-FLYWCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FLYWCH1-low versus FLYWCH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLYWCH1→partner) and Y-score (partner→FLYWCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.772	+3.189	.005	.010	3	2
UCEC	Fibronectin →	-0.349	-2.584	.023	.011	3	1
UCEC	p62 Lck ligand →	+0.531	+3.331	<.001	.005	3	1
UCEC	STAT5a →	+0.415	+3.169	.026	.019	2	1
UCEC	Caspase-8 →	-0.284	-3.321	.015	.010	2	1
UCEC	Annexin-1 →	+0.721	+2.584	.003	.011	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Caspase-7-cleavedD198 by FLYWCH1 expression — UCEC

Explore this box plot interactively →