FLYWCH1

Across TCGA cell cohorts, FLYWCH1 mutation is significantly associated with the RNA expression of many other genes, with 116 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FLYWCH1-associated genes across cancer lineages are CCL8, HMHB1, and OR1J2. Each is linked with FLYWCH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FLYWCH1-to-partner and partner-to-FLYWCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL8 grouped by FLYWCH1-low versus FLYWCH1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLYWCH1→partner) and Y-score (partner→FLYWCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCL8 →	+0.273	+3.865	.001	.006	3	1
SOFT_TISSUE	HMHB1 →	+0.371	+3.635	.001	.007	3	1
SOFT_TISSUE	OR1J2 →	+0.032	+3.635	<.001	.007	3	1
LARGE_INTESTINE	TULP2 →	+0.102	+2.382	.001	.006	3	1
LARGE_INTESTINE	KCNA7 →	+0.168	+2.906	<.001	.001	3	1
LARGE_INTESTINE	TMEM147 →	+0.503	+3.087	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 116 associations by consensus.

CCL8 by FLYWCH1 expression — SOFT_TISSUE

Explore this box plot interactively →