FLYWCH1

Across TCGA cell cohorts, FLYWCH1 mutation is significantly associated with the mutation status of many other genes, with 2,239 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FLYWCH1-associated genes across cancer lineages are KCNC4, ZNF536, and TMEM200C. Each is linked with FLYWCH1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FLYWCH1-to-partner and partner-to-FLYWCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNC4 grouped by FLYWCH1-low versus FLYWCH1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLYWCH1→partner) and Y-score (partner→FLYWCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KCNC4 →	+4.083	+3.338	.003	.003	1	4
LARGE_INTESTINE	ZNF536 →	+1.264	+1.993	.009	.009	1	4
BONE	TMEM200C →	+5.437	+5.437	.003	.003	1	3
LUNG_SCLC	AHDC1 →	+3.651	+4.777	.002	.002	1	3
STOMACH	CENPF →	+3.942	+4.584	.002	.002	1	3
STOMACH	TMEM132B →	+4.942	+4.942	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,239 associations by consensus.

KCNC4 by FLYWCH1 expression — BLOOD_Leukemia

Explore this box plot interactively →