FLT4

Across TCGA patient cohorts, FLT4 mutation is significantly associated with the RNA expression of many other genes, with 7,435 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLT4-associated genes across cancer lineages are MND1, NUDT15, and SGO2. Each is linked with FLT4 in more than 5 cancer types. Because this analysis shows association rather than direction, both FLT4-to-partner and partner-to-FLT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MND1 grouped by FLT4-low versus FLT4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLT4→partner) and Y-score (partner→FLT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MND1 →	+0.991	+3.193	<.001	.009	3	6
UCEC	NUDT15 →	+0.436	+2.021	<.001	<.001	3	6
SKCM	SGO2 →	+0.508	+1.634	.004	<.001	3	6
UCEC	WDR76 →	+0.667	+1.847	<.001	<.001	3	5
LUAD	E2F2 →	+0.830	+3.596	<.001	.001	3	5
UCEC	MYO19 →	+0.432	+1.662	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,435 associations by consensus.

MND1 by FLT4 expression — LUAD

Explore this box plot interactively →