FLT4

Across TCGA patient cohorts, FLT4 mutation is significantly associated with the total protein of many other genes, with 86 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLT4-associated genes across cancer lineages are PDCD4, Cyclin-B1, and CDK1. Each is linked with FLT4 in more than 3 cancer types. Because this analysis shows association rather than direction, both FLT4-to-partner and partner-to-FLT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by FLT4-low versus FLT4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLT4→partner) and Y-score (partner→FLT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PDCD4 →	-0.872	-3.000	<.001	.034	3	4
UCEC	Cyclin-B1 →	+0.612	+3.321	<.001	<.001	3	4
UCEC	CDK1 →	+0.100	+1.289	.017	.021	3	4
STAD	PCNA →	+0.240	+3.169	.034	.017	3	3
UCEC	eIF4E →	+0.189	+3.183	.001	<.001	3	3
STAD	ER-alpha →	-0.200	-2.584	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

PDCD4 by FLT4 expression — LUAD

Explore this box plot interactively →