FLT4

Across TCGA cell cohorts, FLT4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,910 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FLT4-associated GO terms across cancer lineages are Protein-RNA complex assembly, Heterochromatin formation, and Transcription initiation at RNA polymerase II promoter. Each is linked with FLT4 in more than 9 cancer types. Because this analysis shows association rather than direction, both FLT4-to-partner and partner-to-FLT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein-RNA complex assembly grouped by FLT4-low versus FLT4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FLT4→partner) and Y-score (partner→FLT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein-RNA complex assembly →	+0.087	+1.964	<.001	<.001	3	10
BONE	Heterochromatin formation →	+0.074	+1.729	.002	<.001	3	10
BONE	Transcription initiation at RNA polymerase II promoter →	+0.082	+2.129	<.001	<.001	3	10
BONE	Regulation of monoatomic ion transmembrane transport →	-0.099	-2.432	<.001	<.001	3	10
BONE	Epigenetic regulation of gene expression →	+0.051	+1.573	.003	<.001	3	9
BONE	Negative regulation of gene expression, epigenetic →	+0.085	+1.742	.004	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,910 associations by consensus.

Protein-RNA complex assembly by FLT4 expression — BONE

Explore this box plot interactively →