FLT4

Across TCGA cell cohorts, FLT4 mutation is significantly associated with the RNA expression of many other genes, with 586 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FLT4-associated genes across cancer lineages are OR2T12, HES3, and DEFB126. Each is linked with FLT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FLT4-to-partner and partner-to-FLT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T12 grouped by FLT4-low versus FLT4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLT4→partner) and Y-score (partner→FLT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR2T12 →	+0.352	+4.392	<.001	.004	3	2
CNS	HES3 →	+0.044	+5.321	<.001	.005	3	2
LUNG_SCLC	DEFB126 →	+0.104	+3.817	<.001	.004	3	2
OVARY	PROP1 →	+0.018	+3.643	<.001	.002	3	2
OVARY	OR2D3 →	+0.023	+3.405	<.001	.005	3	2
BLOOD_Leukemia	ATG4C →	+0.458	+3.303	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 586 associations by consensus.

OR2T12 by FLT4 expression — SOFT_TISSUE

Explore this box plot interactively →