FLT3

Across TCGA patient cohorts, FLT3 protein abundance is significantly associated with the RNA expression of many other genes, with 1,223 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FLT3-associated genes across cancer lineages are SRRD, TFIP11, and TCF20. Each is linked with FLT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FLT3-to-partner and partner-to-FLT3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FLT3 versus SRRD in OV, with a Pearson correlation of -0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLT3→partner) and Y-score (partner→FLT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SRRD →	-0.718	-0.903	<.001	.005	3	1
OV	TFIP11 →	-0.959	-0.898	<.001	.001	3	1
OV	TCF20 →	-0.951	-1.022	.001	.002	3	1
OV	PACSIN2 →	-0.754	-1.336	.001	.001	3	1
OV	HMGXB4 →	-0.704	-0.903	<.001	.005	3	1
OV	DNAJC5 →	-0.842	-0.948	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,223 associations by consensus.

FLT3 vs SRRD — OV

Explore this scatter interactively →