FLT3

Across TCGA patient cohorts, FLT3 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLT3-associated genes across cancer lineages are GAPDH, INPP4B, and ATM. Each is linked with FLT3 in more than 3 cancer types. Because this analysis shows association rather than direction, both FLT3-to-partner and partner-to-FLT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by FLT3-low versus FLT3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLT3→partner) and Y-score (partner→FLT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	GAPDH →	+0.699	+3.000	.016	.035	3	4
UCEC	INPP4B →	-0.210	-1.807	.027	.003	3	3
UCEC	ATM →	-0.618	-2.723	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.614	+1.604	<.001	.005	3	3
LUSC	p53 →	+0.356	+3.000	.014	.033	3	2
LUSC	Dvl3 →	+0.282	+2.468	<.001	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

GAPDH by FLT3 expression — LUSC

Explore this box plot interactively →