FLT1

Across TCGA pan-cancer cohorts, FLT1 Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated FLT1 data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FLT1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated FLT1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, UCS, and STAD are the cancer types where FLT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.937	0.433	.013	26	view →
UCS	DFS	Median	All	0.090	0.532	<.001	18	view →
STAD	DFS	Median	II,III,IV	0.894	0.352	.013	16	view →
CESC	OS	Median	III,IV	0.068	0.756	<.001	12	view →
KIRP	OS	Median	All	0.157	0.704	.005	12	view →
READ	DFS	Median	All	0.182	0.798	.010	9	view →
PRAD	DFS	Median	All	0.174	0.888	<.001	6	view →
SARC	DFS	Median	All	0.322	0.617	.019	6	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
OV	OS	Median	III,IV	0.797	0.311	.048	2	view →
ESCA	DFS	Median	II,III,IV	0.951	0.469	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

FLT1–UCEC (DFS)

Open the UCEC breakdown →