FLT1

Across TCGA pan-cancer cohorts, FLT1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FLT1 data layer compared with 23 for mass-spec protein and 13 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FLT1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FLT1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where FLT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.411	0.726	<.001	52	view →
LUAD	OS	Median	All	0.754	0.904	.013	24	view →
HNSC	OS	Median	All	1.000	0.497	.046	4	view →
CCRCC	OS	Median	IV	1.000	0.202	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FLT1–PDAC (OS)

Open the PDAC breakdown →