FLT1

Across TCGA patient cohorts, FLT1 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FLT1-associated genes across cancer lineages are Cyclin-B1, eEF2, and MEK1. Each is linked with FLT1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FLT1-to-partner and partner-to-FLT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by FLT1-low versus FLT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLT1→partner) and Y-score (partner→FLT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.603	+1.887	<.001	<.001	3	4
COAD	eEF2 →	+0.422	+2.815	.009	.036	3	3
UCEC	MEK1 →	+0.458	+1.887	<.001	<.001	3	3
COAD	PCNA →	+0.270	+2.815	.047	.036	3	3
UCEC	eIF4E →	+0.188	+1.710	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.190	-1.263	.004	.016	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Cyclin-B1 by FLT1 expression — UCEC

Explore this box plot interactively →