FLT1

Across TCGA cell cohorts, FLT1 mutation is significantly associated with the RNA expression of many other genes, with 605 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FLT1-associated genes across cancer lineages are OR10A5, CPN1, and FLG2. Each is linked with FLT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FLT1-to-partner and partner-to-FLT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A5 grouped by FLT1-low versus FLT1-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FLT1→partner) and Y-score (partner→FLT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OR10A5 →	+0.023	+5.000	<.001	.005	3	3
BLOOD_Leukemia	CPN1 →	+0.114	+2.721	<.001	.002	3	2
BLOOD_Leukemia	FLG2 →	+0.062	+2.493	.001	.003	3	2
BLOOD_Leukemia	LRIT1 →	+0.017	+2.877	<.001	.002	3	2
BLOOD_Leukemia	C16orf92 →	+0.129	+2.844	<.001	<.001	3	2
BLOOD_Leukemia	IQCF5 →	+0.033	+2.786	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 605 associations by consensus.

OR10A5 by FLT1 expression — KIDNEY

Explore this box plot interactively →